GPCR

GPCR PROGRAM

 

A2A

Adenosine receptor A2A

Class A GPCR involved in regulating myocardial blood flow/ hypertension, the regulation of glutamate and dopamine release.

Good therapeutic candidate for insomnia, pain, depression, drug addiction and Parkinson’s disease.

CX3CR1

CX3C chemokine receptor 1

 

Involved in the adhesion and migration of leukocytes and also is a coreceptor for HIV-1.

Good therapeutic candidate for Alzheimer’s disease and other neurological disorders.

GLP2R

Glucagon-like peptide 2 receptor

GPCR involved in intestinal growth and formation by promoting regeneration of the epithelial surface of the gut and thus is an obvious therapeutic target in the field of gastrointestinal diseases.

Good candidate for neurological disorders and diabetes.

M1

Muscarinic acetylcholine receptor M1

 

Like the other muscarinic receptors, its mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

Good therapeutic candidate for Schizophrenia and Alzheimers.

MT1

Melatonin receptor 1

GPCR that modulates neuronal firing, arterial vasocon-striction, cell proliferation in cancer cells, and reproductive and metabolic functions.

Good therapeutic candidate for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer and neurodegenerative diseases.

MT2

Melatonin receptor 2

GPCR found primarily in the retina and brain.

Good therapeutic candidate for melatonin dependent neurobiological dysfunction and diabetes.

UNDISCLOSED

Orphan G-protein coupled receptor

 

Homologous to odorant GPCR.

Good candidate for cancer treatment.