Ion Channels

ION CHANNELS PROGRAM

 

 

KCC2

The Neuron-specific K-Cl Cotransporter

 

Active Cl− extrusion pathway important in postsynaptic inhibition.

Good candidate for different neurological diseases including pain and epilepsy.

 

M2

M2 influenza Proton channel

 

Cell surface protein of the influenza virus that function as proton selective ion channel integral in the viral envelope of the influenza virus. The channel is a homotetramer of four identical units.

Good therapeutic candidate for the blockage of the virus from the host cell entry.

SR-ca-ATPase

Sarcoplasmic reticulum (SR) Ca-ATPase

The Ca-ATPase of the sarcoplasmic reticulum (SR) is a membrane protein that couples the hydrolysis of a molecule of ATP to the active transport of two Ca2+ ions.

Good therapeutic candidate for human heart failure and other cardiovascular diseases.

 

TWIK1

Tandem of P domains in a weak inwardly rectifying K channel1

 

K channel involved in physiological functions such as cell-volume regulation, apoptosis, adrenal gland development and neuronal excitability.

 Good therapeutic candidate for cardiac diseases.

 

UNDISCLOSED

Cation voltage gated channel

 

A voltage gated cation channel involved in the generation and conduction of action potentials.

Good candidate for pain indications.