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Antibody Discovery
Vaccine Discovery
Immunoassays
Drug Discovery
Products and services
CALIXAR delivers the highest-quality membrane proteins used for (bio)drug discovery. Our products and services are adapted to pharmaceutical companies, biotechnology companies, as well as academic teams that are involved in life science.
Our membrane proteins are among the best in the world for developing antibodies, formulating vaccines and/or discovering primary leads through Structure-Based Drug Design or High Throughput Screening assays.
CALIXAR has developed surfactant-based detergents that maintain the functional and structural integrity of membrane proteins. Our technology is unique as we do not require refolding, mutagenesis, truncation, or fusion. Our patented technology has a significant impact on membrane protein’s conformity and quality.
CALIXAR guides its clients for defining the best expression systems or relevant primary cells for specific targets. Our technology is crucial to the success of discovery programs and we also provide assistance to ensure that the expression system of choice is well aligned with the biological questions that need to be addressed.
Pipeline
CALIXAR’s technology is capable of producing high quality, native, wild-type, unaltered, unmutated and untruncated targets for antibody development and drug discovery projects. We are unique in the market and are at the forefront of Membrane Protein technology.
Due to our patented technology and expertise, we are able to manufacture membrane proteins that sustain the structure and function of the target. Our membrane proteins are pure, native, unaltered and stable. They are also able to bind to a wide and broad scope of compounds including agonists, antagonists, and allosteric modulators.
Gain exclusivity with our technology to compose your very own and unique customized membrane proteins. CALIXAR’s technology can equip you with unique targets for your biotech projects found nowhere else in the world.
fEATURES AND BENEFITS
Conventional approaches tend to modify the protein through deletions or point mutations to make it adapted to the environment. Instead, CALIXAR’s approach modifies the chemical environment that will adapt to the proteins/antigens chemistry.
Our process permits the preservation of the functional and structural integrities of the targets/antigens. This has a significantly positive result on the quality of the protein and on the success of the proteomics and drug discovery applications.
Uncover reliable and efficient drugs and antibodies as they are not locked in any particular conformation.
Our high-quality membrane proteins are adapted to application in pharmaceutical, biotechnology firms, and academic teams.
Antibodies (nanobodies, scaffold proteins, aptamers, Small molecules, 3D Structures (X-ray or XFEL, Cryo-EM, NMR)
CALIXAR is the preeminent lab to produce native, wild-type, unmutated and untruncated targets for drug/antibody/vaccine discovery.
All of our clients gain access to our proprietary technology and expertise. (7 patent families, 20 publications).
Purified membrane proteins are adapted to drug discovery, antibody development and drug validation at any clinical stage.
Applications
The CALIXAR® platform utilizes patented technology only available for clients under specific agreements (license, co-development, and service).
You can leverage our proprietary technology as well as other best-in-class membrane protein technology that is not available anywhere else on the market.
CALIXAR conducts exhaustive internal research efforts on specific membrane antigens adapted to discovery projects.
CALIXAR’s antibody expertise produces native and stable membrane proteins for conformational antibody discovery.
CALIXAR’s technology manufactures full length, highly pure membrane proteins via native isolation used for drug discovery projects.
About us
Our approach assists pharmaceutical firms that require access to high-quality targets or antigens for antibody development, vaccine formulation and/or primary lead discovery via Structure-Based Drug Design and or High Throughput Screening Assays.
First in market
CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.
Better discovery
Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.
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Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.
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