This KCC family of transporters (potassium chloride co-transporters) is of high interest to drug discovery. Information described in this chapter, written by Anass JAWHARI , Chief Scientific Officer at CALIXAR, can be useful for all companies in pharmaceutical area. CALIXAR team is very active in this field, in particular with previous work about KKC2.
CALIXAR is a French company which offers a unique and patented technological platform to isolate in solution native full-length membrane proteins, while keeping their structural and functional integrity. With this high quality, membrane targets are often the key for successful discovery programs.
For more details on this approach: CALIXAR’s work on KKC protein family