Anass JAWHARI (CSO) will be presenting new functional architecture of potassium chloride co-transporter KCC2 on March 8th 2018 during the COST Action Meeting in Dublin.
KCC2 is a neuron specific K+-Cl- co-transporter that controls neuronal chloride homeostasis, and is critically involved in many neurological diseases including brain trauma, epilepsies, autism and schizophrenia. The finding highlights the flexible multi-domain structure of KCC2 with variable anchoring points at the dimerization interface and an important C-ter extremity providing the first in-depth functional architecture of KCC2.
Additionally, similar native membrane protein stabilization approach enabling NMR-based fragment screening (case study on adenosine receptor) will be described.
COST is an intergovernmental framework for European Cooperation in Science and Technology, allowing the coordination of nationally-funded research on a European level.