Membrane Protein Technology

Discover our patented membrane protein technology and how we custom-implement our expertise into any of your drug discovery projects.

CALIXAR's core business

Our core business is the isolation of native and functional integral membrane proteins, in addition to deorphanization and identification of  membrane protein partners. 

CALIXAR offers a unique and patented technological platform to isolate in solution native full-length membrane proteins, while keeping their structural and functional integrity. This approach allows to guide you in your projects from expression, extraction and purification.

 

The combination of our expertise in biochemistry of integral membrane proteins (IMPs) and the chemistry of stabilizing reagents used for isolating IMPs, put us in a unique position to facilitate your drug discovery projects.

“ Designing the best chemistry to make the best biochemistry”

Dr. Emmanuel DEJEAN, CO Founder, President of CALIXAR

Conventional approaches tend to modify the protein through deletions or point mutations to make it adapted to the environment. Instead, CALIXAR’s approach modifies the chemical environment that will adapt to the proteins/ antigens chemistry.

Therefore, our process allows the conservation of the functional and structural integrities of the targets/ antigens. This has a significant positive impact on the quality of the protein and on the success of drug discovery applications.

Other advantages
working with CALIXAR

Start from where you want

We can start either from your gene sequence, primary cells, recombinant cells, tissues or organs,…

Applicable to any kind of membrane protein

Our technology is applicable to every kind of membrane proteins (GPCRs, Ions Channels, Transporters, Others Antigens, among others) and also to soluble proteins which are difficult to stabilize in solution.

Unique Chemical facilities

Our unique chemical facilities enable us to continuously design new reagents (detergents/ surfactants,…), to identify, isolate, stabilize, and/ or crystallize your targets in the best conditions.

Diversified services

We offer a variety of services: deorphanization, identification, expression, extraction, purification, stabilization, functional assays, X-ray crystallography and detergent quantification.

DSP and USP Compatibility

Expertise highly compatible with downstream processing (DSP) and upstream processing (USP – expression part).