Discover our patented membrane protein technology and how we custom-implement our expertise into any of your drug discovery projects.
Conventional approaches tend to modify the protein through deletions or point mutations to make it adapted to the environment. Instead, CALIXAR’s approach modifies the chemical environment that will adapt to the proteins/ antigens chemistry.
Therefore, our process allows the conservation of the functional and structural integrities of the targets/ antigens. This has a significant positive impact on the quality of the protein and on the success of drug discovery applications.
We can start either from your gene sequence, primary cells, recombinant cells, tissues or organs,…
Our technology is applicable to every kind of membrane proteins (GPCRs, Ions Channels, Transporters, Others Antigens, among others) and also to soluble proteins which are difficult to stabilize in solution.
Our unique chemical facilities enable us to continuously design new reagents (detergents/ surfactants,…), to identify, isolate, stabilize, and/ or crystallize your targets in the best conditions.
We offer a variety of services: deorphanization, identification, expression, extraction, purification, stabilization, functional assays, X-ray crystallography and detergent quantification.
Expertise highly compatible with downstream processing (DSP) and upstream processing (USP – expression part).