Purified Membrane Proteins

Guided entry of tail-anchored proteins factor 1

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.

Native

Stable

Pure

Active protein

Recombinant protein

Human Origin

Entry Name:

GET1_HUMAN

Gene Name:

GET1

Uniprot Accession:

O00258

Origin:

Homo sapiens (Human)

Protein family:

WRB/GET1

Full-length:

174

AA

Mass:

19780

Da

MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS

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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes