Purified Membrane Proteins

Membrane-associated progesterone receptor component 1

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.

Native

Stable

Pure

Active protein

Recombinant protein

Human Origin

Entry Name:

PGRC1_HUMAN

Gene Name:

PGRMC1

Uniprot Accession:

O00264

Origin:

Homo sapiens (Human)

Protein family:

Cytochrome b5, MAPR subfamily

Full-length:

195

Mass:

21671

Sequence

MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes

Membrane-associated progesterone receptor component 1

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