Purified Membrane Proteins

Interleukin-15 receptor subunit alpha

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction.; [Isoform 5]: Does not bind IL15.; [Isoform 6]: Does not bind IL15. {ECO:0000269|}.; [Isoform 7]: Does not bind IL15. {ECO:0000269|}.; [Isoform 8]: Does not bind IL15. {ECO:0000269|}.

Native

Stable

Pure

Active protein

Recombinant protein

Human Origin

Entry Name:

I15RA_HUMAN

Gene Name:

IL15RA

Uniprot Accession:

Q13261

Origin:

Homo sapiens (Human)

Protein family:

nd

Full-length:

267

AA

Mass:

28233

Da

MAPRRARGCRTLGLPALLLLLLLRPPATRGITCPPPMSVEHADIWVKSYSLYSRERYICNSGFKRKAGTSSLTECVLNKATNVAHWTTPSLKCIRDPALVHQRPAPPSTVTTAGVTPQPESLSPSGKEPAASSPSSNNTAATTAAIVPGSQLMPSKSPSTGTTEISSHESSHGTPSQTTAKNWELTASASHQPPGVYPQGHSDTTVAISTSTVLLCGLSAVSLLACYLKSRQTPPLASVEMEAMEALPVTWGTSSRDEDLENCSHHL

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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes