Purified Membrane Proteins

Sodium channel subunit beta-4

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.

Native

Stable

Pure

Active protein

Recombinant protein

Human Origin

Entry Name:

SCN4B_HUMAN

Gene Name:

SCN4B

Uniprot Accession:

Q8IWT1

Origin:

Homo sapiens (Human)

Protein family:

Sodium channel auxiliary subunit SCN4B (TC 8.A.17)

Full-length:

228

Mass:

24969

Sequence

MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes

Sodium channel subunit beta-4

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