Purified Membrane Proteins

CKLF-like MARVEL transmembrane domain-containing protein 4

Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

Native

Stable

Pure

Active protein

Recombinant protein

Human Origin

Entry Name:

CKLF4_HUMAN

Gene Name:

CMTM4

Uniprot Accession:

Q8IZR5

Origin:

Homo sapiens (Human)

Protein family:

Chemokine-like factor

Full-length:

234

Mass:

25828

Sequence

MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA

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Expression systems: bacteria, yeast, insect cells, HEK & CHO mammalian cells
Purified formats: detergents, SMALPs, nanodiscs, proteoliposomes

CKLF-like MARVEL transmembrane domain-containing protein 4

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