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  • COMPANY
    • Expertise
      • Mission
      • Technology
      • Case Studies
        • Adenosine Receptor (A2A)
        • ABC Transporter (BmrA)
        • Bacteriorhodopsin
        • Bcl-2 Associated Athanogene 3 (BAG3)
        • K-Cl co-transporter 2 (KCC2)
        • Influenza A – H1N1 vaccinal preparation
        • Influenza Matrix Protein 2 (M2)
        • Voltage-gated Sodium Channel (Nav1.7)
      • Track Record
    • About Us
    • CALIXAR’s Partners
    • History
    • Business Model
    • Media
      • Press Releases
      • Related News
      • Events
  • PIPELINE
    • Undisclosed Ion Channel
    • Undisclosed Receptor
    • A2A
    • MT1
    • AcrB
    • BmrA
    • KCC2
    • Vaccine Programs
      • HIV
      • Leptospirosis
      • Influenza
  • PRODUCTS
    • Purified Membrane Proteins
      • GPCRs
        • A2A
        • MT1
        • Orphan GPCR
      • Ion Channels
        • KCC2
        • M2
      • Transporters
        • AcrB
        • BmrA
      • Vaccine Programs
        • HIV
        • Leptospirosis
        • Influenza
        • Chickungunya
    • Reagents and Kits
      • Soft Proprietary Detergents
        • CALX8
        • DDG
        • DDTAC
        • DLAC
        • FLAC6
        • ODG
      • Soft Proprietary Stabilization Reagents
        • CALXCHOL
        • CALXGLUK
        • DDLAC
        • FTAC6
        • FTAC8
      • Crystallization Kits
        • C2B
  • SERVICES
    • Production
      • Expression
      • Isolation
    • Identification
      • Proteomic Studies
      • Target Identification
      • Ligand Identification
      • Understanding mechanism of action for targets or ligands
    • Structure Determination
      • Cryo EM studies
      • Crystallogenesis
      • Xray studies
      • 3D Structure Determination
    • Biochemical Assays
      • Structural Assays
      • Functional Assays
      • Stabilization Assays
  • APPLICATIONS
    • Drug Discovery
      • Deorphanization
      • Target Identification
      • Target Validation
      • High Throughput Screening (HTS)
      • Structure Based Drug Design (SBDD)
      • Fragment Based Drug Design (FBDD)
      • Structural Studies (Cryo EM, Xrays, etc)
    • Antibody Discovery
      • Phage Display
      • Yeast Display
      • Immunization
    • Vaccine Discovery
      • Antigen Discovery
      • Vaccine Formulation
      • Anti Bacterial Based Vaccine
      • Anti Viral Based Vaccine
      • Cell Based Vaccine
      • Subunit Antigen Vaccine
      • Split Virus Based Vaccine
    • Immunoassays
  • NEWS
  • CONTACT
  • Protein-Protein Interaction
  • Protein-Ligand Interaction
  • Aggregation Studies
  • Tools for avoiding aggregation
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Membrane Protein Pipeline

No matter the goals of your project or needs of your team, CALIXAR has the most powerful membrane protein services and technology to get you where you want to be.

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OUR PIPELINE

A2A

CALIXAR’s A2A GPCR aids in the discovery, improvement, and validation of therapeutic antibodies, as well as insomnia, Alzheimer and Parkinson diseases.

MT1

CALIXAR's MT1 GPCR assists in the discovery, improvement, validation of new molecules and therapeutic antibodies for CNS neuroprotection.

AcrB

CALIXAR’s AcrB transporter aids in the identification, development, refinement, and validation of new molecules and therapeutic antibodies.

BmrA

CALIXAR’s BmrA transporter acts as a mechanical pump for ATP dependent drug efflux. This unique characteristic makes BmrA transporters a powerful therapeutic target for multi-drug resistance studies.

KCC2

CALIXAR’s KCC2 ion channel assists in the discovery and validation of new molecules or antibodies. They are ideal candidates for neurological diseases like pain and epilepsy.

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Secure and boost your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.

  • Conformational antibody development
  • Vaccine development
  • High-throughput ligand screening
  • Structure-based drug discovery
  • Immunoassays
  • Deorphanization projects
  • Identification of relevant targets
  • Expression of full-length membrane proteins
  • Functional isolation and stabilization of targets

About

CALIXAR’s approach allows to preserve the original structure and function of membrane proteins (GPCRs, Ion Channels, Transporters, Receptors, Anchors and Viral Proteins) providing solutions for pharmaceutical industries, biotechnology companies and academic teams to develop conformational antibodies, formulate new vaccines, carry out Structure Based Drug Discovery and/or HTS assays.

Headquarters

  • Bâtiment Laennec
    60 avenue Rockefeller
    69008 Lyon - FRANCE
  • +33 481 076 460
  • contact(at)calixar.com

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