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From membrane protein extraction, stabilization, isolation to crystallization, we have the membrane protein detergent / surfactant kits and technology to provide you with high-quality membrane proteins for your discovery projects.
CALIXAR’s membrane protein solubilization, stabilization, and purification techniques require reagents (detergents and surfactants). CALIXAR’s proprietary reagents were developed specifically to meet the unique challenge of membrane proteins. They have been proven to be efficient in more than 170 projects in the production of functional and native membrane proteins.
With our reagent expertise, we have developed membrane protein extraction kits, including soft proprietary detergents and stabilization additives. Our kits enable you to extract, stabilize or purify native membrane complexes from cells using standard laboratory equipment found in all laboratories. Thus, providing you with high-quality membrane proteins for your discovery projects.
Our proprietary detergents and reagents are supplied in powder form which can be directly dissolved in water or organic solvents and provide the following benefits:
Some of our membrane protein reagents are also effective as subcellular fractionation agents, enabling the production of new native antigens to be used, for example, to make inactivated vaccines.
CALIXAR has developed a large range of detergents, reagents, and kits dedicated to membrane proteins. Our molecules are designed and synthesized with chemical properties enabling the native solubilization, stabilization, and or crystallization of membrane targets.
CALIXAR has commercialized a wide range of high-quality products dedicated to the following applications:
Details of Membrane Protein Soft Proprietary Ionic and Non-Ionic Detergents.
Details of Membrane Protein Stabilization – Soft Proprietary Reagents.
CALIXAR’s detergents, reagents, and kits are valuable tools to improve the solubilization, stabilization, and/or the crystallization of all types of membrane proteins (GPCRs, Ion Channels, Transporters). Our molecules can be used alone or in combination with your favorite detergent for your membrane protein. Furthermore, our compounds are compatible with all commercial detergents.
CALIXAR has designed and manufactured custom build surfactant/detergent extraction kits to extract the highest quality membrane proteins that exist today and provide high-quality membrane proteins for discovery projects.
Research scientists from pharmaceutical companies, biotech, and academic groups may take advantage of the CALIXAR’s detergents, reagents, and kits for their R&D projects such as drug discovery programs, structural biology studies, or basic research.
Our molecules are designed to preserve the original structure and function of membrane proteins (GPCRs, Ion Channels, Transporters, Receptors, Anchors and Viral Proteins) providing solutions for pharmaceutical industries, biotechnology companies, and academic teams to develop conformational antibodies, formulate new vaccines, carry out Structure-Based Drug Discovery and/or HTS assays.
CALIXAR’s molecules are dedicated to any life science projects:
Most drug discovery programs and structural biology studies require access to isolated, stable, and functional membrane proteins in solution.
CALIXAR’s detergents and reagents allow the native solubilization and/or stabilization of a wild range of membrane proteins (GPCRs, Ion Channels, Transporters.) expressed in various cell systems (bacteria, yeast, insect cells, mammalian cells…).
In addition, our crystallization kits, dedicated to membrane proteins, assist researchers in their X-ray structural biology projects.
Thanks to CALIXAR’s detergents and reagents, researchers are able to improve the poor solubilization rate and/or the weak stability of their membrane proteins. This makes more membrane targets accessible for R&D projects. Our kits resolve many membrane protein crystallization issues.
CALIXAR’s detergents, reagents, and kits enable researchers to work with membrane proteins in a native process without any denaturing steps. No mutations, truncations, nor modifications are required to improve the stability of the protein. With our tools, you can now isolate your native wild-type, full-length, stable, and functional membrane targets.
Moreover, CALIXAR has developed a large range of detergents, reagents, and kits dedicated to membrane proteins:
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Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.
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