Soft Proprietary Detergents

DDTAC Reagent

CALIXAR’s DDTAC reagent is a non-ionic detergent that can be used to solubilize, extract and stabilize membrane proteins (GPCRs, Ion channels, Transporters, ….).

Purchase DDTAC reagent

Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane) DPn=6

Compound name: (DDLAC) Dodecylmercapto-S(poly(tris(hydroxymethyl) acrylamidomethane)

Catalogue number: DDTAC_250MG,
DDTAC_500MG,
DDTAC_1G

Molec. Formula: na

CAS: nd

MW: ≈1253 g/mol

pKa: na

Percent Composition: na

Physical state: White powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC)b: tR = 11.8 min

CMC: 0.25 mM

Exact mass​: ~0.15 mM

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (15mM), methanol and DMSO

Datasheet

€150.00 (250mg)

ships in 7 business days

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First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We use a unique & tailor-made procedure to give us the edge

CALIXAR’s DDTAC is a very mild detergent used to extract native membrane proteins. DDTAC can solubilize and stabilize more efficiently fragile membrane proteins of high medical relevance.

Our DDTAC is non-ionic and therefore not sensitive to ionic strengths or pH variations and can be customized to solubilize and stabilize specific membrane proteins.

DDTAC helps our clients to produce lipid detergents, mixed micelles and or protein detergent micelles. CALIXAR allows biochemists, structural biologists, pharmacologists and or virologists to work with high-quality DDTAC to extract, solubilize and stabilize native and functional membrane proteins in the solution for research purposes, drug discovery and or target validation.

CALIXAR’s DDTAC is non-ionic and therefore is not sensitive to ionic strength or pH variations and is a very powerful way to extract, solubilize and stabilize particular membrane proteins.

CALIXAR’s DDTAC extracts high-quality membrane proteins that are used in research, drug discovery projects and structural studies. Our DDTAC  is used by pharmaceutical and biotechnology companies, as well as life science academic teams (biochemists, structural biologists, pharmacologists, virologists).

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

References

Journal of Bioenergetics and Biomembranes

Hydrogenated and fluorinated surfactants derived from Tris(hydroxymethyl)-acrylamidomethane allow the purification of a highly active yeast F1-F0 ATP-synthase with an enhanced stability.

Talbot J.-C., et al. 2009

Read more

Contact us

Secure and boost your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.

  • Conformational antibody development
  • Vaccine development
  • High-throughput ligand screening
  • Structure-based drug discovery
  • Immunoassays
  • Deorphanization projects
  • Identification of relevant targets
  • Expression of full-length membrane proteins
  • Functional isolation and stabilization of targets

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Or leave us an email : contact(at)calixar.com