Soft Proprietary Detergents

DDTAC Reagent

CALIXAR’s DDTAC reagent is a non-ionic detergent that can be used to solubilize, extract and stabilize membrane proteins (GPCRs, Ion channels, Transporters, ….).

Purchase DDTAC reagent

Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane) DPn=6

Information

Compound name: (DDTAC) Dodecylmercapto-S(poly(tris(hydroxymethyl) acrylamidomethane)

Catalogue number: DDTAC_250MG,
DDTAC_500MG,
DDTAC_1G

Molec. Formula: na

CAS: 112-55-0

MW: ≈1253 g/mol

pKa: na

Percent Composition: na

Production

Physical state: White powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC)b: tR = 11.8 min

CMC: 0.14 mM

Exact mass: nd

Stability: Store in <-20°C out of direct light

Solubility Structure: Soluble in water (15mM), methanol and DMSO

€165.00 (250mg)

Ships in 7 business days

First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We use a unique & tailor-made procedure to give us the edge

CALIXAR’s DDTAC is a very mild detergent used to extract native membrane proteins. DDTAC can solubilize and stabilize more efficiently fragile membrane proteins of high medical relevance.

Our DDTAC is non-ionic and therefore not sensitive to ionic strengths or pH variations and can be customized to solubilize and stabilize specific membrane proteins.

DDTAC helps our clients to produce lipid detergents, mixed micelles and or protein detergent micelles. CALIXAR allows biochemists, structural biologists, pharmacologists and or virologists to work with high-quality DDTAC to extract, solubilize and stabilize native and functional membrane proteins in the solution for research purposes, drug discovery and or target validation.

Native Full-Length Proteins

CALIXAR’s DDTAC is non-ionic and therefore is not sensitive to ionic strength or pH variations and is a very powerful way to extract, solubilize and stabilize particular membrane proteins.

Specifically Made for Biotech

CALIXAR’s DDTAC extracts high-quality membrane proteins that are used in research, drug discovery projects and structural studies. Our DDTAC is used by pharmaceutical and biotechnology companies, as well as life science academic teams (biochemists, structural biologists, pharmacologists, virologists).

For Any Life Science Project

Antibodies (including nanobodies, scaffold proteins, aptamers)
Small molecules
3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
Antibody discovery (Immunization and display technologies)
Clinical stage (drug validation on reliable native DDLAC)

References

Journal of Bioenergetics and Biomembranes

Hydrogenated and fluorinated surfactants derived from Tris(hydroxymethyl)-acrylamidomethane allow the purification of a highly active yeast F1-F0 ATP-synthase with an enhanced stability.

Talbot J.-C., et al. 2009