CALIXAR extends and completes chemistry and biochemistry tools to isolate full-length membrane proteins with the highest levels of purity while retaining their structural and functional integrity.
One of the limitations of membrane protein structural biology is expressing the membrane protein of interest. The challenge lies in not only expressing the protein of interest but also expressing it to a high level in its native conformity.
CALIXAR’s pipeline provides targets involved in a wide range of diseases and can be helpful for many discovery programs. Thanks to our expertise in purified membrane proteins, CALIXAR produces the best targets on the membrane protein market.
All actors involved in life science projects can benefit from purified membrane proteins: pharmaceutical companies, biotechnology companies, and academic research centers.
Membrane proteins are insoluble in water and have poor stability outside their native membrane environment. Therefore, their extraction from the membrane is a major challenge and may result in denaturation and/or aggregation of the protein once removed from their native environment. This is a critical step that represents the main obstacle for membrane proteins biochemistry and structural biology.
To study the function and structure of membrane proteins, high quantities of pure and stable proteins are needed. All purified membrane proteins of CALIXAR have produced in the best conditions to preserve their stability, their full functionality, and their purity. Our proteins allow our customers to start their work with biological material of extreme accuracy, allowing them to carry out their experiments in the best conditions.