CALIXAR’s membrane protein ion channel targets are used by pharmaceutical companies in their quest for new antibody discovery, vaccine development, validation of rare molecules and new therapeutic antibodies.
Present in the membranes of all living cells, ion channels are pore-forming proteins that ensure the flow of charged ions from one side of a membrane to the other.
Currently, the second largest target for existing drugs after GPCRs are ion channels, which represent promising targets for the development of additional, novel therapeutic agents in the near future.
CALIXAR’s technology, which provides fully native ion channels for successful drug discovery programs, will contribute to this expansion.
Ion channels are often large membrane proteins that may assemble in multimeric forms. The instability of the proteins or complexes can limit biological and structural developments.
Thanks to our patented molecules, CALIXAR’s ion channels are thermostable and functional.
CALIXAR provides our clients with the highest quality membrane ion channel proteins isolated in solution. CALIXAR’s ion channels are full-length, wild-type, pure, functional, and compatible with High Throughput Screening, immunizations, and structural studies by cryo-EM or X-Ray crystallography.