History

2018

CALIXAR named best inventor 2018 of the French Auvergne-Rhône Region among French-Tech start-up companies.
Podium presentation held at the 5^th NoValiX Conference in Boston to highlight new published work on adenosine receptor (A2A).
Peer-reviewed article accepted on a new class of innovative detergents designed to tackle the problem of membrane proteins instability in collaboration with P. FALSON and A. BOUMENDJEL’s laboratory (Angewandte Chemie).
Peer-reviewed article accepted on native GPCR biochemistry and stabilization in collaboration with the Institute of Analytical Sciences and Cochin Institute (Scientific Reports).
New review published on the solubilization and stabilization of wild-type and full-length membrane proteins (Methods).
First CHEM2STAB review accepted on the development of a novel innovative detergent family for membrane-protein extraction (Methods).

2017

Three podium presentations held at World Vaccine Congress to highlight the potential of CALIXAR expertise in vaccine antigen preparation.
Three peer-reviewed articles accepted on membrane protein biochemistry and structural biology in collaboration with ASTRAZENECA, INMED, IGBMC and IBCP.
Launching of CALIXAR catalogue of products and first contracts concluded with SAPPHIRE NORTH AMERICA and G-BIOSCIENCES for the distribution of membrane proteins and reagents.
New CALIXAR™ C2B Additive Kit for crystallization launched and distributed by MOLECULAR DIMENSIONS.
New patent published on antigen identification for Leptospirosis virulence (issued from the COVALEPT consortium with Merial, Genostar, Vetagro-Sup and Institut Pasteur).
New patent published on new calixarene glycoside detergent and its use for extraction and stabilization of native functional membrane proteins.
CALIXAR as invited speaker at Brussels University (VIB) membrane protein workshop.

2016

Extension of strategic compounds portfolio for complex pharmaceutical targets isolation (new patent)
French Inter-Ministry Fund award granted to 3-year program (Chikvax) for developing new vaccine against Chikungunya
New review on “Overcoming bottlenecks in the membrane protein structural biology pipeline” (with Aston University)
Official launch of the common laboratory CHEM2STAB with the University of Avignon
New article published on novel Solubilization and Separation method (Analytical Biochemistry)
New article published on native and functional ion channel isolation (Protein expression and purification)

2015

New US Business Office opened in Cambridge, Massachusetts
Patent on native isolation platform for complex therapeutic targets and antigens extended in Japan
Bio’Innov Competitiveness’ Award upon the Entrepreneurship Spring Event
€1 Million ($1,13 Million) second round funding with historical investors to license-out isolation technologies for complex therapeutic targets and viral antigens

2014

Participation in the COST ion channel network project on the immune response
New patent on innovative manufacturing process for high performance influenza vaccines
Collaboration with Aston University on Multidrug Resistance Targets
New patent on strategic compounds for complex pharmaceutical target isolation

2013

2012

€0,87 Million ($1.2 Million) first round funding with regional angels funds (Health Angels Rhone-Alpes, Veymont Finance, Grenoble Angels, Savoie Angels) and one VCs (Siparex)
Involvement in COVALEPT project with SANOFI group, as leader for discovering and isolating new targets for leptospirosis vaccine development

2011

CALIXAR founded by Emmanuel DEJEAN, Pierre FALSON (Research Director at the French National Research Center) and INP Entreprise as first investor