• CALIXAR named best inventor 2018 of the French Auvergne-Rhône Region among French-Tech start-up companies.
  • Podium presentation held at the 5th NoValiX Conference in Boston to highlight new published work on adenosine receptor (A2A).
  • Peer-reviewed article accepted on a new class of innovative detergents designed to tackle the problem of membrane proteins instability in collaboration with P. FALSON and A. BOUMENDJEL’s laboratory (Angewandte Chemie).
  • Peer-reviewed article accepted on native GPCR biochemistry and stabilization in collaboration with the Institute of Analytical Sciences and Cochin Institute (Scientific Reports).
  • New review published on the solubilization and stabilization of wild-type and full-length membrane proteins (Methods).
  • First CHEM2STAB review accepted on the development of a novel innovative detergent family for membrane-protein extraction (Methods).


  • Three podium presentations held at World Vaccine Congress to highlight the potential of CALIXAR expertise in vaccine antigen preparation.
  • Three peer-reviewed articles accepted on membrane protein biochemistry and structural biology in collaboration with ASTRAZENECA, INMED, IGBMC and IBCP.
  • Launching of CALIXAR catalogue of products and first contracts concluded with SAPPHIRE NORTH AMERICA and G-BIOSCIENCES for the distribution of membrane proteins and reagents.
  • New CALIXAR™ C2B Additive Kit for crystallization launched and distributed by MOLECULAR DIMENSIONS.
  • New patent published on antigen identification for Leptospirosis virulence (issued from the COVALEPT consortium with Merial, Genostar, Vetagro-Sup and Institut Pasteur).
  • New patent published on new calixarene glycoside detergent and its use for extraction and stabilization of native functional membrane proteins.
  • CALIXAR as invited speaker at Brussels University (VIB) membrane protein workshop.


  • Extension of strategic compounds portfolio for complex pharmaceutical targets isolation (new patent)
  • French Inter-Ministry Fund award granted to 3-year program (Chikvax) for developing new vaccine against Chikungunya
  • New review on “Overcoming bottlenecks in the membrane protein structural biology pipeline” (with Aston University)
  • Official launch of the common laboratory CHEM2STAB with the University of Avignon
  • New article published on novel Solubilization and Separation method (Analytical Biochemistry)
  • New article published on native and functional ion channel isolation (Protein expression and purification)


  • New US Business Office opened in Cambridge, Massachusetts
  • Patent on native isolation platform for complex therapeutic targets and antigens extended in Japan
  • Bio’Innov Competitiveness’ Award upon the Entrepreneurship Spring Event
  • €1 Million ($1,13 Million) second round funding with historical investors to license-out isolation technologies for complex therapeutic targets and viral antigens


  • Participation in the COST ion channel network project on the immune response
  • New patent on innovative manufacturing process for high performance influenza vaccines
  • Collaboration with Aston University on Multidrug Resistance Targets
  • New patent on strategic compounds for complex pharmaceutical target isolation


  • Strategic marketing agreement with ABL Inc
  • Innovation Prize from Rhône County
  • New Calixarene additive kit for crystallization


  • €0,87 Million ($1.2 Million) first round funding with regional angels funds (Health Angels Rhone-Alpes, Veymont Finance, Grenoble Angels, Savoie Angels) and one VCs (Siparex)
  • Involvement in COVALEPT project with SANOFI group, as leader for discovering and isolating new targets for leptospirosis vaccine development


  • CALIXAR founded by Emmanuel DEJEAN, Pierre FALSON (Research Director at the French National Research Center) and INP Entreprise as first investor