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Publications using CALIXAR Protein Products

GPCRs

Adenosine receptor A2A

SCIENTIFIC REPORTS
Enabling STD-NMR fragment screening using stabilized native GPCR : A case study of adenosine receptor
Igonet S et al. 2018
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DISCOVERY ON TARGET
Towards Native and Stable GPCRs for Conformational Antibody Development
Jawhari A. Boston, 2019
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ANALYTICAL BIOCHEMISTRY
Novel systematic detergent screening method for membrane proteins solubilization.
Desuzinges Mandon E. et al. 2017
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Melatonin receptor type 1A

MOLECULAR & CELLULAR PROTEOMICS
Purification and identification of G protein-coupled receptor protein complexes under native conditions
Daulat AM. Et al. 2017
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ANALYTICAL BIOCHEMISTRY
Novel systematic detergent screening method for membrane proteins solubilization.
Desuzinges Mandon E. et al. 2017
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Ion channels

Solute carrier family 12 member 5

SCIENTIFIC REPORTS
Molecular architecture of potassium chloride co-transporter KCC2
Agez M et al. 2017
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DISCOVERY ON TARGET
Towards Native and Stable GPCRs for Conformational Antibody Development
Jawhari A. Boston, 2015
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ANALYTICAL BIOCHEMISTRY
Novel systematic detergent
Desuzinges Mandon E. et al. 2017
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Transporters

Multidrug efflux pump subunit AcrB

PROC NATL ACAD SCI USA
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Eicher T. et al. 2012
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ACTA CRYSTALLOGR BIOL CRYSTALLOGR
Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein.
Pos KM. et al. 2002
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Multidrug resistance ABC transporter ATP-binding/permease protein BmrA

ANALYTICAL BIOCHEMISTRY
Novel systematic detergent
Desuzinges Mandon E. et al. 2017
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PLOS ONE
Structuring detergents for extracting and stabilizing functional membrane proteins.
Matar-Merheb R. et al. 2011
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BIOCHEM J.
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state.
Stéphanie Ravaud et al. 2017
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Expertise
High Quality Proprietary Process
Case Studies
Track Record
Publications
Expression of fully native proteins
Identification of relevant targets
Target functional isolation and stabilization
Active custom proteins
Structure-based drug discovery
Immunoassays
Vaccine development
Functional antigen discovery
Conformational antibody development
Expression of fully native proteins
Identification of relevant targets
Target functional isolation and stabilization
Active custom proteins
Structure-based drug discovery
Functional antigen discovery

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Starting from native material or recombinant systems, we succeed with all types of proteins: Kinases, Phosphatases, Ubiquitins, Epigenetic Proteins, GPCRs, Ion Channels, Transporters, Receptors and Viral Proteins.

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