CHK1, active
N-terminal GST-tagged recombinant, human full length CHK1.
No items found.
Biological information
Background
Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK1 regulates numerous checkpoint pathways, including S-phase and G2-M checkpoints. Other potential CHK1 functions include replication, chromatin remodelling and DNA repair. CHK1 inhibitors may sensitize tumors to chemotherapy and radiotherapy.
GenBank AF016582
Target class
Kinase
Family
CAMK
Accession number
NM_001274.3
Target Name
CHK1, active
Target Alias
CHEK1, CHK1
Origin
Human
Theori. MW
81.6 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK1 regulates numerous checkpoint pathways, including S-phase and G2-M checkpoints. Other potential CHK1 functions include replication, chromatin remodelling and DNA repair. CHK1 inhibitors may sensitize tumors to chemotherapy and radiotherapy.
GenBank AF016582
Compound name
Kinase
Catalog number
14-346
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-346
Datasheet