Casein Kinase 2α, active
6His-tagged recombinant, human full length Casein Kinase 2α.
No items found.
Biological information
Background
Mammalian casein kinase 2α1 (CK2a1) is a highly conserved serine-threonine protein kinase that is constitutively expressed in all eukaryotic cell types including yeast, insects, and vertebrates. The enzyme can utilize GTP or ATP as a phosphate donor. Casein kinase activity is stimulated by mitogens in a cell type-specific manner during development and embryogenesis. Inhibition of CK2α1 may be useful in the treatment of human squamous cell carcinoma, adenocarcinoma of the lung, prostatic hyperplasia and lymphomas.
GenBank J02853.1
Target class
Kinase
Family
CMGC
Accession number
EMBL J02853
Target Name
Casein Kinase 2α, active
Target Alias
CSNK2A1, CK2A1, CKIIAlpha, CKII, CK2 Subunit Alpha
Origin
Human
Theori. MW
48.7 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
Mammalian casein kinase 2α1 (CK2a1) is a highly conserved serine-threonine protein kinase that is constitutively expressed in all eukaryotic cell types including yeast, insects, and vertebrates. The enzyme can utilize GTP or ATP as a phosphate donor. Casein kinase activity is stimulated by mitogens in a cell type-specific manner during development and embryogenesis. Inhibition of CK2α1 may be useful in the treatment of human squamous cell carcinoma, adenocarcinoma of the lung, prostatic hyperplasia and lymphomas.
GenBank J02853.1
Compound name
Kinase
Catalog number
14-445
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-445
Datasheet