CSK, active
Recombinant, human full length CSK, containing an N-terminal GST-tag incorporating a PreScission Protease cleavage site.
No items found.
Biological information
Background
CSK (C-SRC, c-src tyrosine kinase) is a non-receptor tyrosine kinase that catalyzes the tyrosine phosphorylation of Src family members at C-terminal, promoting an intramolecular association between the phosphotyrosine and the Src homology 2 (SH2) domain and negatively regulating Src catalytic activity in vivo. Although CSK has substantial homology to Src kinases, it lacks the C-terminal regulatory tyrosine found in Src kinases.
GenBank X60114 (CDS GB 30314)
Target class
Kinase
Family
TK
Accession number
NM_004383.1
Target Name
CSK, active
Target Alias
CSK, MGC117393
Origin
Human
Theori. MW
77.6 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli BL21 (DE3) cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
CSK (C-SRC, c-src tyrosine kinase) is a non-receptor tyrosine kinase that catalyzes the tyrosine phosphorylation of Src family members at C-terminal, promoting an intramolecular association between the phosphotyrosine and the Src homology 2 (SH2) domain and negatively regulating Src catalytic activity in vivo. Although CSK has substantial homology to Src kinases, it lacks the C-terminal regulatory tyrosine found in Src kinases.
GenBank X60114 (CDS GB 30314)
Compound name
Kinase
Catalog number
14-458
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-458
Datasheet