IKKα, active
N-terminal GST-tagged recombinant, human full length IKKα full length.
No items found.
Biological information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
Target class
Kinase
Family
Other
Accession number
NM_001278.3
Target Name
IKKα, active
Target Alias
CHUK, NFKBIKA, IKKA, IKK-A, IKBKA, IKK1, IKK-alpha, IkBKA, TCF16
Origin
Human
Theori. MW
111.6 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
Compound name
Kinase
Catalog number
14-461
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-461
Datasheet