Cdk7/Cyclin H/MAT1 (CAK complex), active
Complex of recombinant, human full length cdk7, containing a C-terminal 6His-tag, recombinant, human full length cyclin H untagged and recombinant, human full length MAT1 containing an N-terminal GST-tag.
No items found.
Biological information
Background
Cyclin-dependent Kinase 7 (cdk7) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
GenBank X79193 / GenBank U11791 / GenBank X87843
Target class
Kinase
Family
CMGC
Accession number
NM_001799.2
Target Name
Cdk7/Cyclin H/MAT1 (CAK complex), active
Target Alias
CDK7, p39MO15, CAK, CAK1, MO15, CDKN7, STK1
Origin
Human
Theori. MW
39.9 kDa (cdk7), 37.8 kDa (cyclin H), 62.8 kDa (MAT1)
Affinity tag
GST, 6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Cyclin-dependent Kinase 7 (cdk7) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
GenBank X79193 / GenBank U11791 / GenBank X87843
Compound name
Kinase
Catalog number
14-476
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-476
Datasheet