Bmx, active
N-terminal 6His-tagged recombinant, human full length Bmx.
No items found.
Biological information
Background
BMX (also called ETK, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase) is one of the non-receptor tyrosine kinases, located intracellularly. It is a src homolog and contains an SH3 and SH2 domain upstream from the tyrosine kinase domain. Unlike other members of the BTK family kinases, which are mostly hemopoietic cell-specific, BMX is preferentially expressed in epithelial and endothelial cells of large arteries. Inhibitors of BMX may be useful in the treatment of atherosclerosis and cancer.
GenBank NM_001721
Target class
Kinase
Family
TK
Accession number
NM_001721.4; NM_203281.1
Target Name
Bmx, active
Target Alias
BMX, PSCTK2, PSCTK3, NTK38, ETK
Origin
Human
Theori. MW
79 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
BMX (also called ETK, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase) is one of the non-receptor tyrosine kinases, located intracellularly. It is a src homolog and contains an SH3 and SH2 domain upstream from the tyrosine kinase domain. Unlike other members of the BTK family kinases, which are mostly hemopoietic cell-specific, BMX is preferentially expressed in epithelial and endothelial cells of large arteries. Inhibitors of BMX may be useful in the treatment of atherosclerosis and cancer.
GenBank NM_001721
Compound name
Kinase
Catalog number
14-499
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-499
Datasheet