Akt3/PKBγ (S472D), active
N-terminal 6His-tagged recombinant, human Akt3/PKBγ amino acids 117-end, containing a S472D mutation.
No items found.
Biological information
Background
AKT (also called protein kinase B) is a serine/threonine protein kinase that has been implicated in mediating a variety of biological responses including inhibiting apoptosis and stimulating cellular growth. Three mammalian isoforms (AKT1, AKT2, and AKT3) of the kinase have been identified.
EMBL AF124141. The recombinant protein contains an amino acid substitution, S472D, with reference toEMBL AF124141. This mutation mimics phosphorylation of S472.
Target class
Kinase
Family
AGC
Accession number
NM_005465.3; NM_181690.1
Target Name
Akt3/PKBγ (S472D), active
Target Alias
AKT3, PRKBG, DKFZP434N0250, PKBG, RAC-gamma, RAC-PK-gamma, STK-2
Origin
Human
Theori. MW
43 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
AKT (also called protein kinase B) is a serine/threonine protein kinase that has been implicated in mediating a variety of biological responses including inhibiting apoptosis and stimulating cellular growth. Three mammalian isoforms (AKT1, AKT2, and AKT3) of the kinase have been identified.
EMBL AF124141. The recombinant protein contains an amino acid substitution, S472D, with reference toEMBL AF124141. This mutation mimics phosphorylation of S472.
Compound name
Kinase
Catalog number
14-502
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-502
Datasheet