Aurora A, active
N-terminal 6His-tagged recombinant, human full length Aurora A.
No items found.
Biological information
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
AGC
Accession number
NM_003600
Target Name
Aurora A, active
Target Alias
AURKA, STK7, AURA, AIK, hARK1, BTAK, AURORA2, aurora-A, Aurora-A, STK15, AurA, ARK1, MGC34538, STK6
Origin
Human
Theori. MW
46.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.
GenBank NM_003600. The recombinant protein also contains the conflict I31F with respect toGenBank NM_003600. This substitution is reported inGenBank NM_003158 and BC027464. The residue coordinates in the native sequence are given.
Compound name
Kinase
Catalog number
14-511
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-511
Datasheet