Axl, active
N-terminal 6His-tagged recombinant, human Axl amino acids 473-end.
No items found.
Biological information
Background
AXL is a member of AXL protein-tyrosine kinase family and expressed human myeloid leukemia cells. Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, was identified as a ligand for the Axl/Sky family of receptor tyrosine kinases. Gas6/Axl signaling has been related to the cell growth and protection from apoptosis in normal and cancer cells.
GenBank NM_021913. The recombinant protein also contains the conflict Q764R with respect toGenBank NM_021913. This substitution is reported in GenBank BC032229. The residue coordinates in the native sequence are given.
Target class
Kinase
Family
TK
Accession number
NM_001699.3; NM_021913.2
Target Name
Axl, active
Target Alias
AXL, UFO
Origin
Human
Theori. MW
48 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
AXL is a member of AXL protein-tyrosine kinase family and expressed human myeloid leukemia cells. Gas6, the protein product of the growth arrest-specific gene 6 (gas6), a member of the vitamin K-dependent protein family, was identified as a ligand for the Axl/Sky family of receptor tyrosine kinases. Gas6/Axl signaling has been related to the cell growth and protection from apoptosis in normal and cancer cells.
GenBank NM_021913. The recombinant protein also contains the conflict Q764R with respect toGenBank NM_021913. This substitution is reported in GenBank BC032229. The residue coordinates in the native sequence are given.
Compound name
Kinase
Catalog number
14-512
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-512
Datasheet