Blk, active
N-terminal 6His-tagged recombinant, human full length Blk.
No items found.
Biological information
Background
Activation of B cells by various ligands is accompanied by activation of src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma.
GenBank M30903. The recombinant protein contains one residue which is in conflict with M30903. This is V421Eand is reported in ESTs BF731187 and BG145526.
Target class
Kinase
Family
Cytosolic tyrosine kinase
Accession number
NM_001715.2
Target Name
Blk, active
Target Alias
BLK, MGC10442
Origin
Mouse
Theori. MW
57.7 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Activation of B cells by various ligands is accompanied by activation of src-family protein tyrosine kinases. Cross-linking of the B-cell receptor leads to the activation of src-family PTKs BLK (B-cell lymphocyte kinase), Fyn, and Lyn. Specific B and T cell progenitor subsets are preferentially susceptible to transformation by BLK and suggest a role for BLK in the control of proliferation during B cell development. BLK protein tyrosine kinase is found primarily in hematopoietic cells and inhibitors may be of therapeutic use in the treatment of B cell lymphoma.
GenBank M30903. The recombinant protein contains one residue which is in conflict with M30903. This is V421Eand is reported in ESTs BF731187 and BG145526.
Compound name
Kinase
Catalog number
14-517
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-517
Datasheet