Casein Kinase 1δ (aa 1-294), active
N-terminal GST-tagged recombinant, human CK1 delta amino acids 1-294.
No items found.
Biological information
Background
Mammalian casein kinase 1 (CK1, ) gene family consists of seven different genes in mammals, CKIa, b, g1, g2, g3, d and e. These enzymes are important components of signal transduction pathways and regulate cell growth, division and differentiation, and the activities of a variety of oncoproteins and transcription factors. CSNK1D (Casein kinase I delta isoform, CKI-delta, CKId) plays an important role in cell survival and protects regulatory proteins from caspase-mediated degradation in apoptosis. Inhibitors may find clinical use for the treatment of Alzheimer’s disease and amyotrophic lateral sclerosis.
GenBank AB063114. This is a rat cDNA that is 100% identical to human casein kinase 1 delta over 1-294 of the predicted amino acid sequence.
Target class
Kinase
Family
CK1
Accession number
NM_001893.3; NM_139062.1
Target Name
Casein Kinase 1δ (aa 1-294), active
Target Alias
CSNK1D, CKI-delta, HCKID, CKId
Origin
Human
Theori. MW
61 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -20°C
Usage disclaimer
For Research Only
Chemical data
Background
Mammalian casein kinase 1 (CK1, ) gene family consists of seven different genes in mammals, CKIa, b, g1, g2, g3, d and e. These enzymes are important components of signal transduction pathways and regulate cell growth, division and differentiation, and the activities of a variety of oncoproteins and transcription factors. CSNK1D (Casein kinase I delta isoform, CKI-delta, CKId) plays an important role in cell survival and protects regulatory proteins from caspase-mediated degradation in apoptosis. Inhibitors may find clinical use for the treatment of Alzheimer’s disease and amyotrophic lateral sclerosis.
GenBank AB063114. This is a rat cDNA that is 100% identical to human casein kinase 1 delta over 1-294 of the predicted amino acid sequence.
Compound name
Kinase
Catalog number
14-520
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-520
Datasheet