Arg, active
N-terminal 6His-tagged recombinant, human Arg, amino acids 38-end.
No items found.
Biological information
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Target class
Kinase
Family
TK
Accession number
NM_005158.2; NM_007314.1
Target Name
Arg, active
Target Alias
ABL2, Abelson-related, ABLL, ARG
Origin
Mouse
Theori. MW
124.5 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The mammalian Abelson (Abl) family of nonreceptor tyrosine kinases is comprised of c-Abl (ABL1) and Arg (Abl-related gene, ABL2), which are encoded by the Abl1 and Abl2 genes, respectively. Deregulation of the c-Abl and Arg tyrosine kinases can occur as a result of chromosomal translocation events that produce chimeric proteins associated with the development of human leukemias as well as gastric cancer invasion and progression.
GenBank XM_136360. The recombinant protein also contains 2 residues which are in conflict withGenBank XM_136360. These are M982V, reported inGenBank NM_005158, NM_007314, M35296, and an A inserted at position 562, reported inGenBank U40827. The residue coordinates in the native sequence have been given.
Compound name
Kinase
Catalog number
14-521
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-521
Datasheet