JNK3/SAPK1b, unactive
N-terminal 6His-tagged recombinant, human JNK3/SAPK1b.
Biological information
Background
INK3, also known as SAPK 1b (Stress-Activated Protein Kinase 1b), is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.
The JNK3 protein sequence is identical to the human JNK3/SAPK1b described inGenBank NM_138980. The DNA sequence, however, is more closely related to the rat cDNA described inGenBank NM_012806.
Target class
Kinase
Family
CMGC
Accession number
NM_002753.2; NM_138980.1; NM_138981.1; NM_138982.1
Target Name
JNK3/SAPK1b, unactive
Target Alias
MAPK10, JNK3A, p54bSAPK, PRKM10, FLJ12099, JNK3, FLJ33785, MGC50974, p493F12
Origin
Human
Theori. MW
53 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
INK3, also known as SAPK 1b (Stress-Activated Protein Kinase 1b), is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.
The JNK3 protein sequence is identical to the human JNK3/SAPK1b described inGenBank NM_138980. The DNA sequence, however, is more closely related to the rat cDNA described inGenBank NM_012806.
Compound name
Kinase
Catalog number
14-523
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-523
Datasheet