CaM Kinase IV, active
C-terminal 6His-tagged recombinant, human full length CaM Kinase IV.
No items found.
Biological information
Background
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Target class
Kinase
Family
CAMK
Accession number
NM_001744.3
Target Name
CaM Kinase IV, active
Target Alias
CAMK4, MGC36771, CaMK-GR
Origin
Human
Theori. MW
52.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Compound name
Kinase
Catalog number
14-547
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-547
Datasheet