EphB2, active
N-terminal 6His-tagged recombinant, human EphB2 amino acids 560-end.
No items found.
Biological information
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. The primary function of EphB2 (Ephrin type-B receptor 2, DRT, EPTH3, ERK, HEK5) is to inactivate the Ras-MAPK pathway in a fashion that contributes to cytoskeletal reorganization and adhesion responses in neuronal growth cones.
GenBank D31661. The recombinant protein is A848S and K918E with respect to this accession number. Both of these conflicts are reported inGenBank entries L36643, AF025304, NM_004442, NM_017449 and L41939.
Target class
Kinase
Family
TK
Accession number
NM_004442.6; NM_017449.3
Target Name
EphB2, active
Target Alias
EPHB2, EphB2, CAPB, EPHT3, Hek5, DRT, EPTH3, TYRO5, ERK, HEK5, MGC87492, PCBC, Tyro5
Origin
Human
Theori. MW
52 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. The primary function of EphB2 (Ephrin type-B receptor 2, DRT, EPTH3, ERK, HEK5) is to inactivate the Ras-MAPK pathway in a fashion that contributes to cytoskeletal reorganization and adhesion responses in neuronal growth cones.
GenBank D31661. The recombinant protein is A848S and K918E with respect to this accession number. Both of these conflicts are reported inGenBank entries L36643, AF025304, NM_004442, NM_017449 and L41939.
Compound name
Kinase
Catalog number
14-553
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-553
Datasheet