EphB4, active
N-terminal 6His-tagged recombinant, human EphB4 amino acids 561-end.
No items found.
Biological information
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. Expression of the EPB4 (EphB4, Ephrin type-B receptor 4, Tyrosine-protein kinase receptor HTK, EC 2.7.1.112) receptors and their ephrinB ligands play a key role in normal vascular formation as well as in diabetic retinopathy, malignant tumor progression and angiogenesis. Inhibition of EPB4 may be used in the treatment of diabetic renopathy and angioproliferative tumors.
GenBank AY056047
Target class
Kinase
Family
TK
Accession number
NM_004444.4
Target Name
EphB4, active
Target Alias
EPHB4, EphB4, TYRO11, MYK1, Tyro11, HTK
Origin
Human
Theori. MW
51 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. Expression of the EPB4 (EphB4, Ephrin type-B receptor 4, Tyrosine-protein kinase receptor HTK, EC 2.7.1.112) receptors and their ephrinB ligands play a key role in normal vascular formation as well as in diabetic retinopathy, malignant tumor progression and angiogenesis. Inhibition of EPB4 may be used in the treatment of diabetic renopathy and angioproliferative tumors.
GenBank AY056047
Compound name
Kinase
Catalog number
14-554
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-554
Datasheet