EphA4, active
N-terminal 6His-tagged recombinant, human EphA4 amino acids 601-892.
No items found.
Biological information
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EPA4 (EphA4, Ephrin type-A receptor 4, Tyrosine-protein kinase receptor SEK, Receptor protein-tyrosine kinase HEK8) can cross-respond to both ephrin-A and -B. In the final stages of embryogenesis, expression of EphA4 is found predominantly within regions of the central nervous system including the cerebral cortex, striatum, thalamus, hippocampus, and ventral spinal cord. EphA4 null mutant mice showed specific defects in the corticospinal tract. Recently, the Eph-ephrin system has been found to be involved in vascular development, angiogenesis, tumor growth and metastasis as well as regulation of smooth muscle contractility, onset of platelet aggregation and to promote onset, growth and stability of the hemostatic plugs. Inhibition of EPA4 may be used in the treatment of various tumors but may delay wound healing.
GenBank NM_004438
Target class
Kinase
Family
TK
Accession number
NM_004438.3
Target Name
EphA4, active
Target Alias
EPHA4, Hek8, HEK8, EphA4, TYRO1, SEK
Origin
Human
Theori. MW
37 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EPA4 (EphA4, Ephrin type-A receptor 4, Tyrosine-protein kinase receptor SEK, Receptor protein-tyrosine kinase HEK8) can cross-respond to both ephrin-A and -B. In the final stages of embryogenesis, expression of EphA4 is found predominantly within regions of the central nervous system including the cerebral cortex, striatum, thalamus, hippocampus, and ventral spinal cord. EphA4 null mutant mice showed specific defects in the corticospinal tract. Recently, the Eph-ephrin system has been found to be involved in vascular development, angiogenesis, tumor growth and metastasis as well as regulation of smooth muscle contractility, onset of platelet aggregation and to promote onset, growth and stability of the hemostatic plugs. Inhibition of EPA4 may be used in the treatment of various tumors but may delay wound healing.
GenBank NM_004438
Compound name
Kinase
Catalog number
14-574
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-574
Datasheet