FGFR4, active
N-terminal 6His-tagged recombinant, human FGFR4 amino acids 442-755.
No items found.
Biological information
Background
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGFR1 through FGFR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGFR4 (FGFR-4, Fibroblast growth factor receptor 4) is expressed mainly in lung, kidney, pancreas, spleen and developing muscle as well as overexpressed in some human malignancies where it has been implicated in their pathogenesis and progression.
GenBank L03840
Target class
Kinase
Family
TK
Accession number
NM_002011.3; NM_022963.2; NM_213647.1
Target Name
FGFR4, active
Target Alias
FGFR4, TKF, FGFR-4, MGC20292, CD334, JTK2
Origin
Human
Theori. MW
36.4 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGFR1 through FGFR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGFR4 (FGFR-4, Fibroblast growth factor receptor 4) is expressed mainly in lung, kidney, pancreas, spleen and developing muscle as well as overexpressed in some human malignancies where it has been implicated in their pathogenesis and progression.
GenBank L03840
Compound name
Kinase
Catalog number
14-583
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-583
Datasheet