PP1α
Recombinant, human full length PP1α.
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Biological information
Background
PP1α protein is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
GenBank NM_002708. The PP1alpha protein sequence is identical to the human PP1 alpha described inGenBank NM_002708. The DNA sequence, however, is more closely related to the rabbit cDNA described inGenBank X14832.
Target class
Phosphatase
Family
Ser/Thr phosphatase
Accession number
NM_001008709.1; NM_002708.3; NM_206873.1
Target Name
PP1α
Target Alias
PPP1CA, PP-1A, MGC15877, MGC1674, PPP1A
Origin
Human
Theori. MW
37.6 kDa
Affinity tag
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Heparin agarose followed by Q agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
PP1α protein is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
GenBank NM_002708. The PP1alpha protein sequence is identical to the human PP1 alpha described inGenBank NM_002708. The DNA sequence, however, is more closely related to the rabbit cDNA described inGenBank X14832.
Compound name
Phosphatase
Catalog number
14-595
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-595
Datasheet