LKB1/STRADα/MO25α, active
N-terminal 6His-tagged recombinant, human full length LKB1. Provided as a complex with GST-STRADα and GST-MO25α.
No items found.
Biological information
Background
LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
GenBank NM000455 / GenBank AF308302 / GenBank NM_016289
Target class
Kinase
Family
CAMK
Accession number
NM_000455.4
Target Name
LKB1/STRADα/MO25α, active
Target Alias
STK11, PJS, LKB1
Origin
Human
Theori. MW
51 kDa (LKB1), 76 kDa (STRADα), 66 kDa (MO25α)
Affinity tag
GST, 6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography; Ni2+/NTA agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
GenBank NM000455 / GenBank AF308302 / GenBank NM_016289
Compound name
Kinase
Catalog number
14-596
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-596
Datasheet