Flt-3 (D835Y), active
N-terminal GST-tagged recombinant, human Flt3 amino acids 564-end, containing the mutation D835Y.
No items found.
Biological information
Background
The receptor tyrosine kinase FLT-3 (fms-related tyrosine kinase 3, STK1) appears to play an important role in the development of hematopoietic stemcells, dendritic cells, B progenitor cells, and natural killer (NK) cells. On binding FLT3 ligand, the wild-type receptor dimerizes, activating its tyrosine kinase domain with resultant autophosphorylation. RAS-GAP, PLC-g, PI3-kinase, STAT5, and ERK1/2 are important signaling proteins linked to activation of FLT3. FLT3 is aberrantly expressed in the malignant cells in the majority of patients with acute myeloid leukemia (AML).
GeneBank NM_004119
Target class
Kinase
Family
TK
Accession number
NM_004119.2
Target Name
Flt-3 (D835Y), active
Target Alias
FLT3, STK-1, FLK2, CD135, OTTHUMP00000042340, STK1
Origin
Human
Theori. MW
77.4 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
The receptor tyrosine kinase FLT-3 (fms-related tyrosine kinase 3, STK1) appears to play an important role in the development of hematopoietic stemcells, dendritic cells, B progenitor cells, and natural killer (NK) cells. On binding FLT3 ligand, the wild-type receptor dimerizes, activating its tyrosine kinase domain with resultant autophosphorylation. RAS-GAP, PLC-g, PI3-kinase, STAT5, and ERK1/2 are important signaling proteins linked to activation of FLT3. FLT3 is aberrantly expressed in the malignant cells in the majority of patients with acute myeloid leukemia (AML).
GeneBank NM_004119
Compound name
Kinase
Catalog number
14-610
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-610
Datasheet