Brk, active
N-terminal 6His-tagged recombinant, human full length BRK.
No items found.
Biological information
Background
BRK (breast tumor kinase, PTK6) is a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. BRK overexpression is frequently observed in breast cancer and several other cancer types. Studies reveal BRK translocates to membrane ruffles, where it colocalizes with paxillin during cell migration. Inhibition of BRK may be useful for the treatment of breast and other cancers.
GenBank NM_005975
Target class
Kinase
Family
TK
Accession number
NM_005975.2
Target Name
Brk, active
Target Alias
PTK6, FLJ42088, BRK
Origin
Human
Theori. MW
55.3 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
BRK (breast tumor kinase, PTK6) is a nonreceptor tyrosine kinase containing SH3, SH2, and tyrosine kinase catalytic domains. BRK overexpression is frequently observed in breast cancer and several other cancer types. Studies reveal BRK translocates to membrane ruffles, where it colocalizes with paxillin during cell migration. Inhibition of BRK may be useful for the treatment of breast and other cancers.
GenBank NM_005975
Compound name
Kinase
Catalog number
14-613
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-613
Datasheet