HIPK2, active
N-terminal 6His-tagged recombinant, human HIPK2 amino acids 165-564.
No items found.
Biological information
Background
Homeodomain-interacting protein kinase 2 (HIPK2), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK2 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK2 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK2 may inhibit apoptosis and facilitate tumorigenesis.
GenBank AF326592. The recombinant protein contains the amino acid substitution I471N (native coordinates) with respect toGenBank AF326592. This conflict is reported inGenBank accession nos. AF207702, AF208291, NM022740.
Target class
Kinase
Family
CMGC
Accession number
NM_022740.2
Target Name
HIPK2, active
Target Alias
HIPK2, PRO0593, hHIPk2
Origin
Human
Theori. MW
49.6 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Homeodomain-interacting protein kinase 2 (HIPK2), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK2 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK2 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK2 may inhibit apoptosis and facilitate tumorigenesis.
GenBank AF326592. The recombinant protein contains the amino acid substitution I471N (native coordinates) with respect toGenBank AF326592. This conflict is reported inGenBank accession nos. AF207702, AF208291, NM022740.
Compound name
Kinase
Catalog number
14-623
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-623
Datasheet