JAK3, active
N-terminal 6His-tagged recombinant, human JAK3 amino acids 781-end.
No items found.
Biological information
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Target class
Kinase
Family
TK
Accession number
NM_000215.2
Target Name
JAK3, active
Target Alias
JAK3, JAKL, LJAK, JAK3_HUMAN, L-JAK, JAK-3
Origin
Human
Theori. MW
39.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Janus kinase 3 (JAK3) is a nonreceptor tyrosine kinase belonging to the Janus family. It is activated by a variety of cytokine and growth factor receptors, resulting in signaling cascades that facilitate the activation of various downstream target genes. JAK3 mediates gene transcription through its well-characterized downstream signaling molecules, the signal transducers and activators of transcription proteins (STAT). Inhibition of JAK3 may impair erythropoietin (EPO)-induced erythropoeiesis and protection from bain damage following hypoxia. Inhibition may also adversely effect diabetes.
GenBank AF513860
Compound name
Kinase
Catalog number
14-629
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-629
Datasheet