DMPK, active
6His-tagged recombinant, human DMPK amino acids 1-549.
No items found.
Biological information
Background
Myotonic dystrophy (DM1) is the most common form of muscular dystrophy in adults, caused by amplification of an unstable (CTG)n repeat in the 3' untranslated region (3'-UTR) of the DM1 protein kinase (DMPK) gene. Myotonic dystrophy protein kinase (DMPK) is a serine threonine kinase encoded by the DM-1 locus.
GenBank NM_004409
Target class
Kinase
Family
AGC
Accession number
NM_001081560.1; NM_001081562.1; NM_001081563.1; NM_004409.3
Target Name
DMPK, active
Target Alias
DMPK, DM-kinase, MDPK, MT-PK, DM, DM1, DMK, DM1PK
Origin
Human
Theori. MW
65 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Myotonic dystrophy (DM1) is the most common form of muscular dystrophy in adults, caused by amplification of an unstable (CTG)n repeat in the 3' untranslated region (3'-UTR) of the DM1 protein kinase (DMPK) gene. Myotonic dystrophy protein kinase (DMPK) is a serine threonine kinase encoded by the DM-1 locus.
GenBank NM_004409
Compound name
Kinase
Catalog number
14-649
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-649
Datasheet