eEF-2K, active
N-terminal GST-tagged recombinant, human eEF-2K amino acids 2-end.
No items found.
Biological information
Background
eEF-2K is a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
GenBank NM_013302. The recombinant protein contains the amino acid substitution H23R with reference to NM_013302. This conflict is reported inGenBank BC032665 and EST BM469975.
Target class
Kinase
Family
Other
Accession number
NM_013302.3
Target Name
eEF-2K, active
Target Alias
EEF2K, MGC45041, HSU93850, eEF-2K
Origin
Human
Theori. MW
108.5 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
eEF-2K is a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
GenBank NM_013302. The recombinant protein contains the amino acid substitution H23R with reference to NM_013302. This conflict is reported inGenBank BC032665 and EST BM469975.
Compound name
Kinase
Catalog number
14-654
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-654
Datasheet