LIM Kinase 1, active
N-terminal 6His-tagged recombinant, human LIM Kinase 1 amino acids 285-638.
No items found.
Biological information
Background
LIM domain kinases 1 and 2 (LIMK1 and LIMK2) play a critical role in stimulus-induced remodeling of the actin cytoskeleton by linking signals from the Rho family GTPases. LIMKs specifically phosphorylate and inactivate cofilin, an actin-binding protein that stimulates depolymerization and severance of actin filaments, thereby regulating actin cytoskeletal reorganization. Inhibition of LIMK1 may be useful in the treatment of tumors, especially invasive breast and prostate cancer cells.
GenBank NM_002314
Target class
Kinase
Family
TKL
Accession number
NM_002314.2
Target Name
LIM Kinase 1, active
Target Alias
LIMK1, LIMK, LIMK-1
Origin
Human
Theori. MW
41.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
LIM domain kinases 1 and 2 (LIMK1 and LIMK2) play a critical role in stimulus-induced remodeling of the actin cytoskeleton by linking signals from the Rho family GTPases. LIMKs specifically phosphorylate and inactivate cofilin, an actin-binding protein that stimulates depolymerization and severance of actin filaments, thereby regulating actin cytoskeletal reorganization. Inhibition of LIMK1 may be useful in the treatment of tumors, especially invasive breast and prostate cancer cells.
GenBank NM_002314
Compound name
Kinase
Catalog number
14-656
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-656
Datasheet