HIPK3, active
N-terminal 6His-tagged recombinant, human HIPK3 amino acids 161-562.
No items found.
Biological information
Background
Homeodomain-interacting protein kinase 3 (HIPK3), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK3 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK3 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK3 may inhibit apoptosis and facilitate tumorigenesis.
GenBank NM_005734
Target class
Kinase
Family
CMGC
Accession number
NM_001048200.1; NM_005734.3
Target Name
HIPK3, active
Target Alias
HIPK3, FIST, DYRK6, ANPK, PKY, YAK1, FIST3
Origin
Human
Theori. MW
49.7 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Homeodomain-interacting protein kinase 3 (HIPK3), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK3 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK3 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK3 may inhibit apoptosis and facilitate tumorigenesis.
GenBank NM_005734
Compound name
Kinase
Catalog number
14-680
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-680
Datasheet