Flt-4, active
N-terminal GST-tagged recombinant, human Flt4 amino acids 800-end.
No items found.
Biological information
Background
Three high affinity VEGF receptors, Flt-1 (VEGFR-1, activated by placental growth factor PlGF), KDR (Flk-1/VEGFR-2, activated by VEGF), and FLT4 (VEGF3, activated by VEGF-related protein (VRP)), have been identified. These receptors can be divided into three structural regions: seven extracellular Ig-like domains that contain the growth factor binding sites, a single polypeptide chain hydrophobic trans-membrane sequence, and intracellular cytoplasmic domains that confer the tyrosine kinase activity required for signal transduction. Tissue expression of the FLT4 receptor is found predominantly in lymphatic and microvascular endothelium and some leukemia cell lines, indicating that this receptor may be a role in the regulation of hematopoiesis.
GenBank NM_182925. The recombinant protein contains the amino acid substitutions V1128L and H1146R with reference to NM_182925. These mutations are reported inGenBank U43143 andGenBank X68203.
Target class
Kinase
Family
TK
Accession number
NM_002020.3; NM_182925.3
Target Name
Flt-4, active
Target Alias
FLT4, PCL, VEGFR-3, FLT41, VEGFR3
Origin
Human
Theori. MW
90.9 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Three high affinity VEGF receptors, Flt-1 (VEGFR-1, activated by placental growth factor PlGF), KDR (Flk-1/VEGFR-2, activated by VEGF), and FLT4 (VEGF3, activated by VEGF-related protein (VRP)), have been identified. These receptors can be divided into three structural regions: seven extracellular Ig-like domains that contain the growth factor binding sites, a single polypeptide chain hydrophobic trans-membrane sequence, and intracellular cytoplasmic domains that confer the tyrosine kinase activity required for signal transduction. Tissue expression of the FLT4 receptor is found predominantly in lymphatic and microvascular endothelium and some leukemia cell lines, indicating that this receptor may be a role in the regulation of hematopoiesis.
GenBank NM_182925. The recombinant protein contains the amino acid substitutions V1128L and H1146R with reference to NM_182925. These mutations are reported inGenBank U43143 andGenBank X68203.
Compound name
Kinase
Catalog number
14-681
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-681
Datasheet