IRAK1, active
N-terminal 6His-tagged recombinant, human IRAK1 amino acids 194-end.
No items found.
Biological information
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Target class
Kinase
Family
TKL
Accession number
NM_001025242.1; NM_001025243.1; NM_001569.3
Target Name
IRAK1, active
Target Alias
IRAK1, IRAK, IRAK-1, pelle
Origin
Human
Theori. MW
59.7 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-κB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-κB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis.
GenBank NM_001569
Compound name
Kinase
Catalog number
14-684
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-684
Datasheet