Casein Kinase 1γ1, active
N-terminal 6His-tagged recombinant, human Casein Kinase 1γ1 amino acids 25-355.
No items found.
Biological information
Background
Mammalian casein kinase 1 (CK1) gene family consists of seven different genes in mammals, CKIa, b, g1, g2, g3, d and e. These enzymes are important component of signal transduction pathways, regulates cell growth, division and differentiation, and the activities of a variety of oncoproteins and transcription factors. CSNK1G1 (Casein kinase I gamma1 isoform) plays an important role in cell survival and protects regulatory proteins from caspase-mediated degradation in apoptosis. Inhibitors may find clinical use for the treatment of Alzheimer’s disease and amyotrophic lateral sclerosis.
GenBank NM_022048
Target class
Kinase
Family
CK1
Accession number
NM_022048.3
Target Name
Casein Kinase 1γ1, active
Target Alias
CSNK1G1
Origin
Human
Theori. MW
41.9 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Mammalian casein kinase 1 (CK1) gene family consists of seven different genes in mammals, CKIa, b, g1, g2, g3, d and e. These enzymes are important component of signal transduction pathways, regulates cell growth, division and differentiation, and the activities of a variety of oncoproteins and transcription factors. CSNK1G1 (Casein kinase I gamma1 isoform) plays an important role in cell survival and protects regulatory proteins from caspase-mediated degradation in apoptosis. Inhibitors may find clinical use for the treatment of Alzheimer’s disease and amyotrophic lateral sclerosis.
GenBank NM_022048
Compound name
Kinase
Catalog number
14-711
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-711
Datasheet