CaM Kinase IIδ, active
N-terminal 6His-tagged recombinant, human full length CaM Kinase IIδ N-terminal 6His-tagged recombinant, human full length CaM Kinase IIδ.
No items found.
Biological information
Background
Calcium/calmodulin dependent protein kinase II (CaMKII) is a serine/threonine kinase which is encoded as over two dozen variants generated by alternative mRNA splicing of 4 genes. CaMKII phosphorylate target proteins in a calcium calmodulin dependent manner and play critical for gene transcription, ion channel activity, cytoskeletal function and carbohydrate metabolism. CaMKII has been implicated in memory and cell growth control as well as in the disorders of cancer, cystic fibrosis, Alzheimerís disease and epilepsy. The overexpression of a specific constitutively active CAMK2D (CaMKIId) in PC-12, P19 and NIH/3T3 cells induces neurite outgrowth.
GenBank NM_172115
Target class
Kinase
Family
CAMK
Accession number
NM_001221.2; NM_172115.1; NM_172127.1; NM_172128.1
Target Name
CaM Kinase IIδ, active
Target Alias
CAMK2D, CAMKD, MGC44911
Origin
Human
Theori. MW
58 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Calcium/calmodulin dependent protein kinase II (CaMKII) is a serine/threonine kinase which is encoded as over two dozen variants generated by alternative mRNA splicing of 4 genes. CaMKII phosphorylate target proteins in a calcium calmodulin dependent manner and play critical for gene transcription, ion channel activity, cytoskeletal function and carbohydrate metabolism. CaMKII has been implicated in memory and cell growth control as well as in the disorders of cancer, cystic fibrosis, Alzheimerís disease and epilepsy. The overexpression of a specific constitutively active CAMK2D (CaMKIId) in PC-12, P19 and NIH/3T3 cells induces neurite outgrowth.
GenBank NM_172115
Compound name
Kinase
Catalog number
14-723
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-723
Datasheet